A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Anne Mette Madsen; Katrine Uhrbrand; Victor Carp Kofoed; Thea K. Fischer; Margit W. Frederiksen

doi:10.1016/j.watres.2023.119625

A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Anne Mette Madsen
, Katrine Uhrbrand
, Victor Carp Kofoed
, Thea K. Fischer
, Margit W. Frederiksen

Department of Clinical Research, Nordsjaellands Hospital, Denmark.
Statens Serum Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

Originalsprog	Engelsk
Tidsskrift	Water Research
Sider (fra-til)	119625
ISSN	0043-1354
DOI	https://doi.org/10.1016/j.watres.2023.119625
Status	Udgivet - jan. 2023

Emneord

Inflammation
LPS
MALDI-TOF MS
Occupational exposure
Occupational exposure limit
Wastewater
Spildevand
Mikrobiologi
Arbejdshygiejne
Luftvejslidelser
Toksikologi
Kemisk arbejdsmiljø

Adgang til dokumentet

10.1016/j.watres.2023.119625

2 Afsluttet

Spildevand, affald og slam – identificering og kvantificering af eksponering for biologiske agenser, risikovurdering og arbejdsbetingede helbredsrisici
Madsen, A. M. (Projektleder), Wagtberg, M. (Projektdeltager) & Møller, S. A. (Projektdeltager)
01/01/2020 → 31/05/2024
Projekter: Projekt › Forskning
Eksponering for luftbårne noro-virus og bakterier på rensningsanlæg og sammenhæng med gastroenteritis
Madsen, A. M. (Projektleder), Abildtrup, A. (Projektdeltager), Uhrbrand, K. (Projektdeltager), Feld, L. (Projektdeltager), Wagtberg, M. (Projektdeltager), Moslehi Jenabian, S. (Projektdeltager), Tegner, U. (Projektdeltager) & Akyol, M. P. (Projektdeltager)
01/12/2013 → 31/10/2016
Projekter: Projekt › Forskning

6 Tidsskriftartikel

Effect of anaerobic digestion on pathogens and antimicrobial resistance in the sewage sludge
Franchitti, E., Pedullà, M., Madsen, A. M. & Traversi, D., sep. 2024, I: Environment International. 191, s. 108998
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Et kohortestudie af eksponering for mikroorganismer og endotoksin på et rensningsanlæg og inflammation
Madsen, A., dec. 2023, I: Miljø og sundhed. 29, 3, s. 15-20
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
Påvirkning af ansatte på et rensningsanlæg for endotoksin
Madsen, A., maj 2023, I: Spildevand. 2, s. 12-13
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

2 Foredrag og mundtlige bidrag
1 Organisation af og deltagelse i konference

Temamøde om det mikrobiologiske arbejdsmiljø
Madsen, A. M. (Arrangør), Kofoed, V. C. (Deltager), Delsuz, M. S. (Deltager) & Vogel, U. B. (Facilitator)
11 dec. 2023
Aktivitet: Deltagelse i eller arrangering af en begivenhed › Organisation af og deltagelse i konference
Mikrobiologisk eksponering i arbejdsmiljøet – helbredseffekter og risikovurdering
Madsen, A. M. (Foredragsholder)
11 okt. 2023
Aktivitet: Tale eller præsentation › Foredrag og mundtlige bidrag
Bioaerosol exposure at the workplace – what do we know and what do we measure - examples from pig farms, greenhouses, and waste workers
Madsen, A. M. (Foredragsholder)
21 mar. 2023
Aktivitet: Tale eller præsentation › Foredrag og mundtlige bidrag

Citationsformater

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title = "A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods",

abstract = "Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p",

keywords = "Inflammation, LPS, MALDI-TOF MS, Occupational exposure, Occupational exposure limit, Wastewater, Spildevand, Mikrobiologi, Arbejdshygiejne, Luftvejslidelser, Toksikologi, Kemisk arbejdsmilj{\o}",

author = "Madsen, \{Anne Mette\} and Katrine Uhrbrand and Kofoed, \{Victor Carp\} and Fischer, \{Thea K.\} and Frederiksen, \{Margit W.\}",

year = "2023",

month = jan,

doi = "10.1016/j.watres.2023.119625",

language = "English",

pages = "119625",

journal = "Water Research",

issn = "0043-1354",

publisher = "Elsevier Limited",

}

A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods. / Madsen, Anne Mette; Uhrbrand, Katrine; Kofoed, Victor Carp et al.
I: Water Research, 01.2023, s. 119625.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

AU - Madsen, Anne Mette

AU - Uhrbrand, Katrine

AU - Kofoed, Victor Carp

AU - Fischer, Thea K.

AU - Frederiksen, Margit W.

PY - 2023/1

Y1 - 2023/1

N2 - Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

AB - Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

KW - Inflammation

KW - LPS

KW - MALDI-TOF MS

KW - Occupational exposure

KW - Occupational exposure limit

KW - Wastewater

KW - Spildevand

KW - Mikrobiologi

KW - Arbejdshygiejne

KW - Luftvejslidelser

KW - Toksikologi

KW - Kemisk arbejdsmiljø

U2 - 10.1016/j.watres.2023.119625

DO - 10.1016/j.watres.2023.119625

M3 - Journal article

SN - 0043-1354

SP - 119625

JO - Water Research

JF - Water Research

ER -

A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Abstract

Emneord

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Citationsformater