Animal testing for acute inhalation toxicity: A thing of the past?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

According to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), testing for acute inhalation toxicity is required for chemicals manufactured or imported at tonnages?≥?10 tons per year. Three OECD test guidelines for acute inhalation toxicity in vivo are adopted (TG 403, TG 436, and TG 433). Since animal testing is ethically, scientifically and economically questionable, adoption of alternative methods by the European Union and the OECD is needed. An in vitro system based on the study of lung surfactant function is introduced.
OriginalsprogEngelsk
TidsskriftApplied In Vitro Toxicology
Vol/bind4
Udgave nummer2
Sider (fra-til)89-90
Antal sider2
ISSN2332-1512
DOI
StatusUdgivet - 22 mar. 2018
  • Lungesurfaktant funktion in vitro - imprægneringsprodukter

    Sørli, J. B. (Projektleder), Abildtrup, A. (Projektdeltager), Terrida, E. B. (Projektdeltager), Hansen, J. S. (Projektdeltager), Hougaard, K. S. (Projektdeltager), Guldbrandsen, M. (Projektdeltager), Nielsen, S. H. (Projektdeltager), Larsen, S. T. (Projektdeltager) & Huang, Y. (Projektdeltager)

    01/07/201530/06/2016

    Projekter: ProjektForskning

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