Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele; K S Hougaard; M Kjølby; M Hokland; G Winther; B Elfving; G Wegener; A L Nielsen; A Larsen; M K Nøhr; S B Pedersen; T Wang; S Lund

doi:10.1038/ijo.2017.136

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

A Dudele
, K S Hougaard
, M Kjølby
, M Hokland
, G Winther
, B Elfving
, G Wegener
, A L Nielsen
, A Larsen
, M K Nøhr
, S B Pedersen
, T Wang
, S Lund

Department of Bioscience, Section for Zoophysiology, Aarhus University, Aarhus, Denmark.
Department of Biomedicine, The Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine and Danish Diabetes Academy, Aarhus University, Aarhus, Denmark.
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, DK-8240, Denmark.
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.

METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.

RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.

CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

Originalsprog	Engelsk
Tidsskrift	International Journal of Obesity
Vol/bind	41
Udgave nummer	9
Sider (fra-til)	1420-1426
Antal sider	7
ISSN	0307-0565
DOI	https://doi.org/10.1038/ijo.2017.136
Status	Udgivet - sep. 2017

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10.1038/ijo.2017.136

Citationsformater

Dudele, A., Hougaard, K. S., Kjølby, M., Hokland, M., Winther, G., Elfving, B., Wegener, G., Nielsen, A. L., Larsen, A., Nøhr, M. K., Pedersen, S. B., Wang, T., & Lund, S. (2017). Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity, 41(9), 1420-1426. https://doi.org/10.1038/ijo.2017.136

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abstract = "BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.",

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year = "2017",

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AU - Dudele, A

AU - Hougaard, K S

AU - Kjølby, M

AU - Hokland, M

AU - Winther, G

AU - Elfving, B

AU - Wegener, G

AU - Nielsen, A L

AU - Larsen, A

AU - Nøhr, M K

AU - Pedersen, S B

AU - Wang, T

AU - Lund, S

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N2 - BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

AB - BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice.METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes.RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood.CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.

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JO - International Journal of Obesity

JF - International Journal of Obesity

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Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

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