GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

O. Raaschou-Nielsen; Mette Sørensen; R.D. Hansen; K. Frederiksen; A. Tjønneland; K. Overvad; Ulla Birgitte Vogel

doi:10.1016/j.canlet.2006.05.006

GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

O. Raaschou-Nielsen
, Mette Sørensen
, R.D. Hansen
, K. Frederiksen
, A. Tjønneland
, K. Overvad
, Ulla Birgitte Vogel

Kemi og mikrobiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1TT carriers than among GPX1CC and GPX1CT carriers.

Originalsprog	Engelsk
Tidsskrift	Cancer Lett
Vol/bind	247
Udgave nummer	2
Sider (fra-til)	293-300
Antal sider	8
ISSN	0304-3835
DOI	https://doi.org/10.1016/j.canlet.2006.05.006
Status	Udgivet - 2007

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10.1016/j.canlet.2006.05.006

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title = "GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer",

abstract = "We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95\% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1TT carriers than among GPX1CC and GPX1CT carriers.",

author = "O. Raaschou-Nielsen and Mette S{\o}rensen and R.D. Hansen and K. Frederiksen and A. Tj{\o}nneland and K. Overvad and Vogel, \{Ulla Birgitte\}",

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T1 - GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

AU - Raaschou-Nielsen, O.

AU - Sørensen, Mette

AU - Hansen, R.D.

AU - Frederiksen, K.

AU - Tjønneland, A.

AU - Overvad, K.

AU - Vogel, Ulla Birgitte

N1 - SUBMISSIONYEAR:2007

PY - 2007

Y1 - 2007

N2 - We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1TT carriers than among GPX1CC and GPX1CT carriers.

AB - We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1TT carriers than among GPX1CC and GPX1CT carriers.

U2 - 10.1016/j.canlet.2006.05.006

DO - 10.1016/j.canlet.2006.05.006

M3 - Journal article

SN - 0304-3835

VL - 247

SP - 293

EP - 300

JO - Cancer Lett

JF - Cancer Lett

IS - 2

ER -

GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

Abstract

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