Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

V. Andersen; J.D. Christensen; K. Overvad; A. Tjønneland; Ulla Birgitte Vogel

doi:10.1097/MEG.0b013e3283417f76

Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

V. Andersen
, J.D. Christensen
, K. Overvad
, A. Tjønneland
, Ulla Birgitte Vogel

Kemi og mikrobiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

Originalsprog	Dansk
Tidsskrift	European Journal of Gastroenterology & Hepatology
Vol/bind	23
Udgave nummer	3
Sider (fra-til)	282-285
Antal sider	4
ISSN	0954-691X
DOI	https://doi.org/10.1097/MEG.0b013e3283417f76
Status	Udgivet - 2011

Adgang til dokumentet

10.1097/MEG.0b013e3283417f76

Citationsformater

@article{eed4d2228f434c289d7f70ed970d6963,

title = "Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study",

abstract = "Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95\% confidence intervals were calculated.Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.",

author = "V. Andersen and J.D. Christensen and K. Overvad and A. Tj{\o}nneland and Vogel, \{Ulla Birgitte\}",

note = "SUBMISSIONYEAR:2011",

year = "2011",

doi = "10.1097/MEG.0b013e3283417f76",

language = "Dansk",

volume = "23",

pages = "282--285",

journal = "European Journal of Gastroenterology \& Hepatology",

issn = "0954-691X",

publisher = "Lippincott, Williams \& Wilkins",

number = "3",

}

TY - JOUR

T1 - Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

AU - Andersen, V.

AU - Christensen, J.D.

AU - Overvad, K.

AU - Tjønneland, A.

AU - Vogel, Ulla Birgitte

N1 - SUBMISSIONYEAR:2011

PY - 2011

Y1 - 2011

N2 - Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

AB - Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

U2 - 10.1097/MEG.0b013e3283417f76

DO - 10.1097/MEG.0b013e3283417f76

M3 - Tidsskriftartikel

SN - 0954-691X

VL - 23

SP - 282

EP - 285

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

IS - 3

ER -