Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data

I E H Madsen; S T Nyberg; L L Magnusson Hanson; J E Ferrie; K Ahola; L Alfredsson; G D Batty; J B Bjorner; M Borritz; H Burr; J-F Chastang; R de Graaf; N Dragano; M Hamer; M Jokela; A Knutsson; M Koskenvuo; A Koskinen; C Leineweber; I Niedhammer; M L Nielsen; M Nordin; T Oksanen; J H Pejtersen; J Pentti; I Plaisier; P Salo; A Singh-Manoux; S Suominen; M Ten Have; T Theorell; S Toppinen-Tanner; J Vahtera; A Väänänen; P J M Westerholm; H Westerlund; E I Fransson; K Heikkilä; M Virtanen; R Rugulies; M Kivimäki; IPD-Work Consortium

doi:10.1017/S003329171600355X

Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data

I E H Madsen
, S T Nyberg
, L L Magnusson Hanson
, J E Ferrie
, K Ahola
, L Alfredsson
, G D Batty
, J B Bjorner
, M Borritz
, H Burr
, J-F Chastang
, R de Graaf
, N Dragano
, M Hamer
, M Jokela
, A Knutsson
, M Koskenvuo
, A Koskinen
, C Leineweber
, I Niedhammer

M L Nielsen, M Nordin, T Oksanen, J H Pejtersen, J Pentti, I Plaisier, P Salo, A Singh-Manoux, S Suominen, M Ten Have, T Theorell, S Toppinen-Tanner, J Vahtera, A Väänänen, P J M Westerholm, H Westerlund, E I Fransson, K Heikkilä, M Virtanen, R Rugulies, M Kivimäki, IPD-Work Consortium

Finnish Institute of Occupational Health, Helsinki, Finland.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
Department of Epidemiology and Public Health,University College London, UK.
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.
INSERM, U1085, Research Institute for Environmental and Occupational Health (IRSET), Epidemiology in Occupational Health and Ergonomics (ESTER) Team, Angers, France.
Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands.
Department of Medical Sociology,University of Düsseldorf,40225 Düsseldorf,Germany.
Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
Department of Public Health, University of Helsinki, Helsinki, Finland.
Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark.
The Danish National Centre for Social Research, Copenhagen,Denmark.
The Netherlands Institute for Social Research,2515 XP The Hague,The Netherlands.
Folkhälsan Research Center,FI-00290 Helsinki,Finland.
Occupational and Environmental Medicine,Uppsala University,SE-751 85 Uppsala,Sweden.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.

METHOD: We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.

RESULTS: We included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81-1.32).

CONCLUSIONS: Job strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.

Originalsprog	Engelsk
Tidsskrift	Psychological Medicine
Vol/bind	47
Udgave nummer	8
Sider (fra-til)	1342-1356
Antal sider	15
ISSN	0033-2917
DOI	https://doi.org/10.1017/S003329171600355X
Status	Udgivet - 2017

Adgang til dokumentet

10.1017/S003329171600355X

Arbejdsmiljø, psykisk helbred og arbejdsmarkedstilknytning i udsatte grupper (AhA)
Madsen, I. E. H. (Projektleder), Hansen, A.-S. K. (Projektdeltager), Thomsen, B. L. R. (Projektdeltager), Christensen, B. (Projektdeltager), Hansen, J. V. (Projektdeltager) & Rugulies, R. (Projektdeltager)
01/07/2012 → 30/06/2016
Projekter: Projekt › Forskning
Metaanalyser med individuelle deltagerdata fra arbejdsmiljøkohorter i internationalt projekt (IPD-Work)
Rugulies, R. (Projektleder), Madsen, I. E. H. (Projektdeltager) & Rugulies, R. (Projektdeltager)
01/04/2010 → 31/12/2020
Projekter: Projekt › Forskning

Citationsformater

Madsen, I. E. H., Nyberg, S. T., Magnusson Hanson, L. L., Ferrie, J. E., Ahola, K., Alfredsson, L., Batty, G. D., Bjorner, J. B., Borritz, M., Burr, H., Chastang, J.-F., de Graaf, R., Dragano, N., Hamer, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Leineweber, C., ... IPD-Work Consortium (2017). Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data. Psychological Medicine, 47(8), 1342-1356. https://doi.org/10.1017/S003329171600355X

@article{6e0482f070f94011af585ef88a604a1e,

title = "Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data",

abstract = "BACKGROUND: Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.METHOD: We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.RESULTS: We included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95\% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95\% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95\% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95\% CI 0.81-1.32).CONCLUSIONS: Job strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.",

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doi = "10.1017/S003329171600355X",

language = "English",

volume = "47",

pages = "1342--1356",

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Madsen, IEH, Nyberg, ST, Magnusson Hanson, LL, Ferrie, JE, Ahola, K, Alfredsson, L, Batty, GD, Bjorner, JB, Borritz, M, Burr, H, Chastang, J-F, de Graaf, R, Dragano, N, Hamer, M, Jokela, M, Knutsson, A, Koskenvuo, M, Koskinen, A, Leineweber, C, Niedhammer, I, Nielsen, ML, Nordin, M, Oksanen, T, Pejtersen, JH, Pentti, J, Plaisier, I, Salo, P, Singh-Manoux, A, Suominen, S, Ten Have, M, Theorell, T, Toppinen-Tanner, S, Vahtera, J, Väänänen, A, Westerholm, PJM, Westerlund, H, Fransson, EI, Heikkilä, K, Virtanen, M, Rugulies, R, Kivimäki, M & IPD-Work Consortium 2017, 'Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data', Psychological Medicine, bind 47, nr. 8, s. 1342-1356. https://doi.org/10.1017/S003329171600355X

TY - JOUR

T1 - Job strain as a risk factor for clinical depression

T2 - systematic review and meta-analysis with additional individual participant data

AU - Madsen, I E H

AU - Nyberg, S T

AU - Magnusson Hanson, L L

AU - Ferrie, J E

AU - Ahola, K

AU - Alfredsson, L

AU - Batty, G D

AU - Bjorner, J B

AU - Borritz, M

AU - Burr, H

AU - Chastang, J-F

AU - de Graaf, R

AU - Dragano, N

AU - Hamer, M

AU - Jokela, M

AU - Knutsson, A

AU - Koskenvuo, M

AU - Koskinen, A

AU - Leineweber, C

AU - Niedhammer, I

AU - Nielsen, M L

AU - Nordin, M

AU - Oksanen, T

AU - Pejtersen, J H

AU - Pentti, J

AU - Plaisier, I

AU - Salo, P

AU - Singh-Manoux, A

AU - Suominen, S

AU - Ten Have, M

AU - Theorell, T

AU - Toppinen-Tanner, S

AU - Vahtera, J

AU - Väänänen, A

AU - Westerholm, P J M

AU - Westerlund, H

AU - Fransson, E I

AU - Heikkilä, K

AU - Virtanen, M

AU - Rugulies, R

AU - Kivimäki, M

AU - IPD-Work Consortium

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.METHOD: We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.RESULTS: We included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81-1.32).CONCLUSIONS: Job strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.

AB - BACKGROUND: Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.METHOD: We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.RESULTS: We included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81-1.32).CONCLUSIONS: Job strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.

KW - Journal Article

U2 - 10.1017/S003329171600355X

DO - 10.1017/S003329171600355X

M3 - Journal article

C2 - 28122650

SN - 0033-2917

VL - 47

SP - 1342

EP - 1356

JO - Psychological Medicine

JF - Psychological Medicine

IS - 8

ER -

Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data

Abstract

Adgang til dokumentet

Fingeraftryk

Projekter

Arbejdsmiljø, psykisk helbred og arbejdsmarkedstilknytning i udsatte grupper (AhA)

Metaanalyser med individuelle deltagerdata fra arbejdsmiljøkohorter i internationalt projekt (IPD-Work)

Citationsformater