Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

Katja Maria Bendtsen; Louise Gren; Vilhelm Berg Malmborg; Pravesh Chandra Shukla; Martin Tunér; Yona J. Essig; Annette M. Krais; Per Axel Clausen; Trine Berthing; Katrin Loeschner; Nicklas Raun Jacobsen; Henrik Wolff; Joakim Pagels; Ulla  Vogel

doi:10.1186/s12989-020-00369-9

Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

Katja Maria Bendtsen, Louise Gren, Vilhelm Berg Malmborg, Pravesh Chandra Shukla, Martin Tunér, Yona J. Essig, Annette M. Krais, Per Axel Clausen, Trine Berthing, Katrin Loeschner, Nicklas Raun Jacobsen, Henrik Wolff, Joakim Pagels, Ulla Vogel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black.

Originalsprog	Engelsk
Artikelnummer	38
Tidsskrift	Particle and Fibre Toxicology
Vol/bind	17
ISSN	1743-8977
DOI	https://doi.org/10.1186/s12989-020-00369-9
Status	Udgivet - 2020

Emneord

Nano

Adgang til dokumentet

10.1186/s12989-020-00369-9

1 Afsluttet

Dansk Center for Nanosikkerhed
Vogel, U. B. (Projektleder), Hougaard, K. S. (Projektdeltager), Frederiksen, M. (Projektdeltager), Clausen, P. A. (Projektdeltager), Saber, A. T. (Projektdeltager), Berthing, T. (Projektdeltager), Jacobsen, N. R. (Projektdeltager), Jensen, K. A. (Projektdeltager), Mortensen, A. (Projektdeltager), Poulsen, S. S. (Projektdeltager), Koivisto, A. J. (Projektdeltager), Jensen, A. C. Ø. (Projektdeltager), Brostrøm, A. (Projektdeltager), Skovmand, A. (Projektdeltager), Andersen, M. H. G. (Projektdeltager) & Koivisto, J. M. (Projektdeltager)
01/05/2016 → 31/08/2019
Projekter: Projekt › Forskning

3 Tidsskriftartikel

Acute phase response as a biological mechanism-of-action of (nano)particle-Induced cardiovascular disease
Hadrup, N., Zhernovkov, V., Jacobsen, N. R., Voss, C., Strunz, M., Ansari, M., Schiller, H. B., Halappanavar, S., Poulsen, S. S., Kholodenko, B., Stoeger, T., Saber, A. T. & Vogel, U., 29 mar. 2020, I: Small. e1907476.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Effect of renewable fuels and intake O2 concentration on diesel engine emission characteristics and Reactive Oxygen Species (ROS) formation
Gren, L., Malmborg, V. B., Jacobsen, N. R., Shukla, P. C., Bendtsen, K. M., Eriksson, A. C., Essig, Y. J., Krais, A. M., Loeschner, K., Shamun, S., Strandberg, B., Tunér, M., Vogel, U. & Pagels, J., jun. 2020, I: ATMOSPHERE. 11, 6, 641.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice
Bendtsen, K. M., Brostrøm, A., Koivisto, A. J., Koponen, I. K., Berthing, T., Bertram, N., Kling, K. I., Dal Maso, M., Kangasniemi, O., Poikkimäki, M., Loeschner, K., Clausen, P. A., Wolff, H., Jensen, K. A., Saber, A. T. & Vogel, U., 11 jun. 2019, I: Particle and Fibre Toxicology. 16, 23.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang

Citationsformater

Bendtsen, K. M., Gren, L., Malmborg, V. B., Shukla, P. C., Tunér, M., Essig, Y. J., Krais, A. M., Clausen, P. A., Berthing, T., Loeschner, K., Jacobsen, N. R., Wolff, H., Pagels, J., & Vogel, U. (2020). Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties. Particle and Fibre Toxicology, 17, Artikel 38. https://doi.org/10.1186/s12989-020-00369-9

@article{9377e1581df44260ada6fcda1dcb3245,

title = "Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties",

abstract = "Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black.",

keywords = "diesel exhaust particles, toxicity, physico-chemical characterisation, gentoxicity, inflammation , acute phase response, Nano",

author = "Bendtsen, {Katja Maria} and Louise Gren and Malmborg, {Vilhelm Berg} and Shukla, {Pravesh Chandra} and Martin Tun{\'e}r and Essig, {Yona J.} and Krais, {Annette M.} and Clausen, {Per Axel} and Trine Berthing and Katrin Loeschner and Jacobsen, {Nicklas Raun} and Henrik Wolff and Joakim Pagels and Ulla Vogel",

year = "2020",

doi = "10.1186/s12989-020-00369-9",

language = "English",

volume = "17",

journal = "Particle and Fibre Toxicology",

issn = "1743-8977",

publisher = "BioMed Central",

}

Bendtsen, KM, Gren, L, Malmborg, VB, Shukla, PC, Tunér, M, Essig, YJ, Krais, AM, Clausen, PA , Berthing, T, Loeschner, K, Jacobsen, NR, Wolff, H, Pagels, J & Vogel, U 2020, 'Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties', Particle and Fibre Toxicology, bind 17, 38. https://doi.org/10.1186/s12989-020-00369-9

Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties. / Bendtsen, Katja Maria; Gren, Louise; Malmborg, Vilhelm Berg et al.
I: Particle and Fibre Toxicology, Bind 17, 38, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

AU - Bendtsen, Katja Maria

AU - Gren, Louise

AU - Malmborg, Vilhelm Berg

AU - Shukla, Pravesh Chandra

AU - Tunér, Martin

AU - Essig, Yona J.

AU - Krais, Annette M.

AU - Clausen, Per Axel

AU - Berthing, Trine

AU - Loeschner, Katrin

AU - Jacobsen, Nicklas Raun

AU - Wolff, Henrik

AU - Pagels, Joakim

AU - Vogel, Ulla

PY - 2020

Y1 - 2020

N2 - Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black.

AB - Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black.

KW - diesel exhaust particles

KW - toxicity

KW - physico-chemical characterisation

KW - gentoxicity

KW - inflammation

KW - acute phase response

KW - Nano

U2 - 10.1186/s12989-020-00369-9

DO - 10.1186/s12989-020-00369-9

M3 - Journal article

SN - 1743-8977

VL - 17

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

M1 - 38

ER -

Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties

Abstract

Emneord

Adgang til dokumentet

Projekter

Dansk Center for Nanosikkerhed

Publikation

Acute phase response as a biological mechanism-of-action of (nano)particle-Induced cardiovascular disease

Effect of renewable fuels and intake O2 concentration on diesel engine emission characteristics and Reactive Oxygen Species (ROS) formation

Airport emission particles: Exposure characterization and toxicity following intratracheal instillation in mice

Citationsformater