Ph.d-vejledning: Semen quality and biomarkers of male fertility following in-utero exposure to persistent and not persistent environmental toxicants

Description

Infertility affects 15–25% of all couples trying to achieve a pregnancy. Male factor infertility accounts for at least one third of the cases. Although much research has been done on male infertility in relation to exposures in adulthood, infertility remains unexplained for many. The focus has, therefore, been expanded to cover exposures during fetal life and early development of the reproductive organs. However, evidence from large-scale epidemiological studies are lacking.
The purpose of this thesis was to investigate if selected exposures in fetal life have long-term consequences for male reproductive function. To examine this, we established the world’s largest male offspring cohort specifically designed to study the fetal programming of semen quality hypothesis. The Fetal Programming of Semen Quality (FEPOS) cohort consists of 1,058 sons participation rate 19%) and their mothers, nested within the Danish National Birth Cohort (DNBC). The sons answered a questionnaire, underwent a clinical examination, and delivered a semen and blood sample. Information on fetal exposures were available from a DNBC interview of the mothers and from a blood sample drawn during pregnancy. (Katia Keglberg Hærvig)

Period	1 Jan 2017 → 1 Jul 2021
Held at	Arbejds- og Miljømedicinsk Afd., BBH. Danmark., Denmark
Degree of Recognition	International