A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Anne Mette Madsen; Katrine Uhrbrand; Victor Carp Kofoed; Thea K. Fischer; Margit W. Frederiksen

doi:10.1016/j.watres.2023.119625

A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Anne Mette Madsen
, Katrine Uhrbrand
, Victor Carp Kofoed
, Thea K. Fischer
, Margit W. Frederiksen

Department of Clinical Research, Nordsjaellands Hospital, Denmark.
Statens Serum Institut

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

Original language	English
Journal	Water Research
Pages (from-to)	119625
ISSN	0043-1354
DOIs	https://doi.org/10.1016/j.watres.2023.119625
Publication status	Published - Jan 2023

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10.1016/j.watres.2023.119625

2 Finished

Spildevand, affald og slam – identificering og kvantificering af eksponering for biologiske agenser, risikovurdering og arbejdsbetingede helbredsrisici
Madsen, A. M. (Project Manager), Wagtberg, M. (Project Participant) & Møller, S. A. (Project Participant)
01/01/2020 → 31/05/2024
Project: Research
EN -Ass. between exposure to airborne noro-virus and bacteria and gastroenteritis
Madsen, A. M. (Project Manager), Abildtrup, A. (Project Participant), Uhrbrand, K. (Project Participant), Feld, L. (Project Participant), Wagtberg, M. (Project Participant), Moslehi Jenabian, S. (Project Participant), Tegner, U. (Project Participant) & Akyol, M. P. (Project Participant)
01/12/2013 → 31/10/2016
Project: Research

6 Journal article

Effect of anaerobic digestion on pathogens and antimicrobial resistance in the sewage sludge
Franchitti, E., Pedullà, M., Madsen, A. M. & Traversi, D., Sept 2024, In: Environment International. 191, p. 108998
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
Et kohortestudie af eksponering for mikroorganismer og endotoksin på et rensningsanlæg og inflammation
Madsen, A., Dec 2023, In: Miljø og sundhed. 29, 3, p. 15-20
Research output: Contribution to journal › Journal article › Research
Påvirkning af ansatte på et rensningsanlæg for endotoksin
Madsen, A., May 2023, In: Spildevand. 2, p. 12-13
Research output: Contribution to journal › Journal article › Communication

2 Lecture and oral contribution
1 Organisation of and participation in conference

Temamøde om det mikrobiologiske arbejdsmiljø
Madsen, A. M. (Organiser), Kofoed, V. C. (Participant), Delsuz, M. S. (Participant) & Vogel, U. B. (Facilitator)
11 Dec 2023
Activity: Participating in or organising an event › Organisation of and participation in conference
Mikrobiologisk eksponering i arbejdsmiljøet – helbredseffekter og risikovurdering
Madsen, A. M. (Speaker)
11 Oct 2023
Activity: Talk or presentation › Lecture and oral contribution
Bioaerosol exposure at the workplace – what do we know and what do we measure - examples from pig farms, greenhouses, and waste workers
Madsen, A. M. (Speaker)
21 Mar 2023
Activity: Talk or presentation › Lecture and oral contribution

Cite this

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title = "A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods",

abstract = "Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p",

keywords = "Inflammation, LPS, MALDI-TOF MS, Occupational exposure, Occupational exposure limit, Wastewater, Spildevand, Mikrobiologi, Arbejdshygiejne, Luftvejslidelser, Toksikologi, Kemisk arbejdsmilj{\o}",

author = "Madsen, \{Anne Mette\} and Katrine Uhrbrand and Kofoed, \{Victor Carp\} and Fischer, \{Thea K.\} and Frederiksen, \{Margit W.\}",

year = "2023",

month = jan,

doi = "10.1016/j.watres.2023.119625",

language = "English",

pages = "119625",

journal = "Water Research",

issn = "0043-1354",

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A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods. / Madsen, Anne Mette; Uhrbrand, Katrine; Kofoed, Victor Carp et al.
In: Water Research, 01.2023, p. 119625.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

AU - Madsen, Anne Mette

AU - Uhrbrand, Katrine

AU - Kofoed, Victor Carp

AU - Fischer, Thea K.

AU - Frederiksen, Margit W.

PY - 2023/1

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N2 - Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

AB - Work in wastewater treatment plants (WWTPs) can be associated with exposure to airborne microorganisms and endotoxin from the working environment. The aim of this study was to obtain knowledge about whether serum levels of the markers of systemic inflammation, C-reactive protein (CRP) and serum amyloid A (SAA), are associated with personal exposure to endotoxin, measured using the Limulus (endotoxinLimulus) and the rFC (endotoxinrFC) assays, as well as bacteria and fungi in a cohort of WWTP workers. Exposure and blood samples were collected for 11 workers over one year. Exposure to endotoxinLimulus-day and endotoxinrFC-day correlated significantly (r=0.80, p

KW - Inflammation

KW - LPS

KW - MALDI-TOF MS

KW - Occupational exposure

KW - Occupational exposure limit

KW - Wastewater

KW - Spildevand

KW - Mikrobiologi

KW - Arbejdshygiejne

KW - Luftvejslidelser

KW - Toksikologi

KW - Kemisk arbejdsmiljø

U2 - 10.1016/j.watres.2023.119625

DO - 10.1016/j.watres.2023.119625

M3 - Journal article

SN - 0043-1354

SP - 119625

JO - Water Research

JF - Water Research

ER -

A cohort study of wastewater treatment plant workers: association between levels of biomarkers of systemic inflammation and exposure to bacteria and fungi, and endotoxin as measured using two methods

Abstract

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Cite this