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Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

  • Ali Kermanizadeh
  • , Trine Berthing
  • , Ewa Guzniczak
  • , Melanie Wheeldon
  • , Graeme Whyte
  • , Ulla Vogel
  • , Wolfgang Moritz
  • , Vicki Stone
  • Heriot Watt University, School of Engineering and Physical Sciences, Edinburgh, UK.
  • InSphero AG, Schlieren, Switzerland.

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Pharmacology, Toxicology and Pharmaceutical Science