TY - JOUR
T1 - Associations of occupational and leisure-time physical activity with all-cause mortality
T2 - an individual participant data meta-analysis
AU - Coenen, Pieter
AU - Huysmans, Maaike A
AU - Holtermann, Andreas
AU - Troiano, Richard P
AU - Mork, Paul Jarle
AU - Krokstad, Steinar
AU - Clays, Els
AU - Cillekens, Bart
AU - De Bacquer, Dirk
AU - Aadahl, Mette
AU - Kårhus, Line Lund
AU - Sjøl, Anette
AU - Andersen, Lars Bo
AU - Kauhanen, Jussi
AU - Voutilainen, Ari
AU - Pulsford, Richard M.
AU - Stamatakis, Emmanuel
AU - Goldbourt, Uri
AU - Peters, Annette
AU - Thorand, Barbara
AU - Rosengren, Annika
AU - Björck, Lena
AU - Sprow, Kyle
AU - Franzon, Kristin
AU - Rodriguez-Barranco, Miguel
AU - Luján-Barroso, Leila
AU - Knutsson, Anders
AU - Alfredsson, Lars
AU - Bahls, Martin
AU - Ittermann, Till
AU - Kluttig, Alexander
AU - Hassan, Lamiaa
AU - Wanner, Miriam
AU - Bopp, Matthias
AU - Marott, Jacob Louis
AU - Schnohr, Peter
AU - Nordestgaard, Børge Grønne
AU - Dalene, Knut Eirik
AU - Ekelund, Ulf
AU - Clausen, Johan
AU - Jensen, Magnus Thorsten
AU - Petersen, Christina Bjørk
AU - Krause, Niklas
AU - Twisk, Jos
AU - Mechelen, Willem van
AU - van der Beek, Allard J
N1 - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2024/9/10
Y1 - 2024/9/10
N2 - OBJECTIVE: Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and leisure-time physical activity (OPA and LTPA) with all-cause mortality.DESIGN: Two-stage individual participant data meta-analysis.DATA SOURCE: Published and unpublished cohort study data.ELIGIBILITY CRITERIA: Working participants aged 18-65 years.METHODS: After data harmonisation, we assessed associations of OPA and LTPA with all-cause mortality. In stage 1, we analysed data from each study separately using Cox survival regression, and in stage 2, we pooled individual study findings with random-effects modelling.RESULTS: In 22 studies with up to 590 497 participants from 11 countries, during a mean follow-up of 23.1 (SD: 6.8) years, 99 743 (16%) participants died. Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively).CONCLUSION: Our findings indicate that OPA may not result in the same beneficial health effects as LTPA.
AB - OBJECTIVE: Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and leisure-time physical activity (OPA and LTPA) with all-cause mortality.DESIGN: Two-stage individual participant data meta-analysis.DATA SOURCE: Published and unpublished cohort study data.ELIGIBILITY CRITERIA: Working participants aged 18-65 years.METHODS: After data harmonisation, we assessed associations of OPA and LTPA with all-cause mortality. In stage 1, we analysed data from each study separately using Cox survival regression, and in stage 2, we pooled individual study findings with random-effects modelling.RESULTS: In 22 studies with up to 590 497 participants from 11 countries, during a mean follow-up of 23.1 (SD: 6.8) years, 99 743 (16%) participants died. Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively).CONCLUSION: Our findings indicate that OPA may not result in the same beneficial health effects as LTPA.
KW - Fysisk aktivitet
KW - review
U2 - 10.1136/bjsports-2024-108117
DO - 10.1136/bjsports-2024-108117
M3 - Journal article
C2 - 39255999
SN - 0306-3674
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
ER -