Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

Petra Jackson; K.I. Kling; Keld Alstrup Jensen; Per Axel Clausen; Anne Mette Madsen; Erik Håkan Richard Wallin; Ulla Birgitte Vogel

doi:10.1002/em.21922

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

Petra Jackson, K.I. Kling, Keld Alstrup Jensen, Per Axel Clausen, Anne Mette Madsen, Erik Håkan Richard Wallin, Ulla Birgitte Vogel

Chemical Working Environment, Toxicology, Nanosafety, and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM-401, NM-402, and NM-403), materials (NRCWE-026 and MWCNT-XNRI-7), and three sets of surface-modified MWCNT grouped by physical characteristics (thin, thick, and short I-III, respectively). Each Groups I-III included pristine, hydroxylated and carboxylated MWCNT. Group III also included an amino-functionalized MWCNT. The level of surface functionalization of the MWCNT was low. The level and type of elemental impurities of the MWCNT varied by

Original language	Danish
Journal	Environmental and Molecular Mutagenesis
Volume	56
Issue number	2
Pages (from-to)	183-203
Number of pages	21
ISSN	0893-6692
DOIs	https://doi.org/10.1002/em.21922
Publication status	Published - 2015

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10.1002/em.21922

Danish NanoSafety Centre
Vogel, U. B. (Project Manager), Hougaard, K. S. (Project Participant), Frederiksen, M. (Project Participant), Clausen, P. A. (Project Participant), Saber, A. T. (Project Participant), Berthing, T. (Project Participant), Jacobsen, N. R. (Project Participant), Jensen, K. A. (Project Participant), Mortensen, A. (Project Participant), Poulsen, S. S. (Project Participant), Koivisto, A. J. (Project Participant), Jensen, A. C. Ø. (Project Participant), Brostrøm, A. (Project Participant), Skovmand, A. (Project Participant), Andersen, M. H. G. (Project Participant) & Koivisto, J. M. (Project Participant)
01/05/2016 → 31/08/2019
Project: Research

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Jackson, P., Kling, K. I., Jensen, K. A., Clausen, P. A., Madsen, A. M., Wallin, E. H. R., & Vogel, U. B. (2015). Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line. Environmental and Molecular Mutagenesis, 56(2), 183-203. https://doi.org/10.1002/em.21922

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title = "Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line",

abstract = "Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM-401, NM-402, and NM-403), materials (NRCWE-026 and MWCNT-XNRI-7), and three sets of surface-modified MWCNT grouped by physical characteristics (thin, thick, and short I-III, respectively). Each Groups I-III included pristine, hydroxylated and carboxylated MWCNT. Group III also included an amino-functionalized MWCNT. The level of surface functionalization of the MWCNT was low. The level and type of elemental impurities of the MWCNT varied by",

author = "Petra Jackson and K.I. Kling and Jensen, \{Keld Alstrup\} and Clausen, \{Per Axel\} and Madsen, \{Anne Mette\} and Wallin, \{Erik H{\aa}kan Richard\} and Vogel, \{Ulla Birgitte\}",

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language = "Dansk",

volume = "56",

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Jackson, P, Kling, KI, Jensen, KA , Clausen, PA , Madsen, AM, Wallin, EHR & Vogel, UB 2015, 'Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line', Environmental and Molecular Mutagenesis, vol. 56, no. 2, pp. 183-203. https://doi.org/10.1002/em.21922

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line. / Jackson, Petra; Kling, K.I.; Jensen, Keld Alstrup et al.
In: Environmental and Molecular Mutagenesis, Vol. 56, No. 2, 2015, p. 183-203.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Jackson, Petra

AU - Kling, K.I.

AU - Jensen, Keld Alstrup

AU - Clausen, Per Axel

AU - Madsen, Anne Mette

AU - Wallin, Erik Håkan Richard

AU - Vogel, Ulla Birgitte

N1 - SUBMISSIONYEAR:2014

PY - 2015

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N2 - Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM-401, NM-402, and NM-403), materials (NRCWE-026 and MWCNT-XNRI-7), and three sets of surface-modified MWCNT grouped by physical characteristics (thin, thick, and short I-III, respectively). Each Groups I-III included pristine, hydroxylated and carboxylated MWCNT. Group III also included an amino-functionalized MWCNT. The level of surface functionalization of the MWCNT was low. The level and type of elemental impurities of the MWCNT varied by

AB - Carbon nanotubes vary greatly in physicochemical properties. We compared cytotoxic and genotoxic response to 15 multiwalled carbon nanotubes (MWCNT) with varying physicochemical properties to identify drivers of toxic responses. The studied MWCNT included OECD Working Party on Manufactured Nanomaterials (WPMN) (NM-401, NM-402, and NM-403), materials (NRCWE-026 and MWCNT-XNRI-7), and three sets of surface-modified MWCNT grouped by physical characteristics (thin, thick, and short I-III, respectively). Each Groups I-III included pristine, hydroxylated and carboxylated MWCNT. Group III also included an amino-functionalized MWCNT. The level of surface functionalization of the MWCNT was low. The level and type of elemental impurities of the MWCNT varied by

U2 - 10.1002/em.21922

DO - 10.1002/em.21922

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JO - Environmental and Molecular Mutagenesis

JF - Environmental and Molecular Mutagenesis

IS - 2

ER -

Characterization of genotoxic response to 15 multiwalled carbon nanotubes with variable physicochemical properties including surface functionalizations in the FE1-Muta(TM) mouse lung epithelial cell line

Abstract

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Projects

Danish NanoSafety Centre

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