DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes.

Ulla Birgitte Vogel; M. Dybdahl; G. Frentz; B.A. Nexø

doi:10.1016/S0921-8777(00)00051-3

DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes.

Ulla Birgitte Vogel
, M. Dybdahl
, G. Frentz
, B.A. Nexø

Department of Chemistry and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We have previously shown that high DNA repair capacity protects psoriasis patients against chemically induced basal cell carcinoma [Dybdahl et al. Mutat. Res. 433 (1999) 15-22]. We have used the same study persons to investigate the correlation between expression of eight genes involved in nucleotide excision repair and DNA repair capacity. mRNA levels of XPA, XPB, XPC, XPD, XPF, XPG, CSB and ERCC1 in primary lymphocytes from 33 individuals were quantified by dot-blots and normalized to -actin. ERCC1 and XPD mRNA quantities were highly correlated (r=0.89; P

Original language	English
Journal	Mutat Res
Volume	461
Issue number	3
Pages (from-to)	197-210
Number of pages	14
ISSN	0027-5107
DOIs	https://doi.org/10.1016/S0921-8777(00)00051-3
Publication status	Published - 2000

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title = "DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes.",

abstract = "We have previously shown that high DNA repair capacity protects psoriasis patients against chemically induced basal cell carcinoma [Dybdahl et al. Mutat. Res. 433 (1999) 15-22]. We have used the same study persons to investigate the correlation between expression of eight genes involved in nucleotide excision repair and DNA repair capacity. mRNA levels of XPA, XPB, XPC, XPD, XPF, XPG, CSB and ERCC1 in primary lymphocytes from 33 individuals were quantified by dot-blots and normalized to -actin. ERCC1 and XPD mRNA quantities were highly correlated (r=0.89; P",

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T1 - DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes.

AU - Vogel, Ulla Birgitte

AU - Dybdahl, M.

AU - Frentz, G.

AU - Nexø, B.A.

N1 - SUBMISSIONYEAR:2000

PY - 2000

Y1 - 2000

N2 - We have previously shown that high DNA repair capacity protects psoriasis patients against chemically induced basal cell carcinoma [Dybdahl et al. Mutat. Res. 433 (1999) 15-22]. We have used the same study persons to investigate the correlation between expression of eight genes involved in nucleotide excision repair and DNA repair capacity. mRNA levels of XPA, XPB, XPC, XPD, XPF, XPG, CSB and ERCC1 in primary lymphocytes from 33 individuals were quantified by dot-blots and normalized to -actin. ERCC1 and XPD mRNA quantities were highly correlated (r=0.89; P

AB - We have previously shown that high DNA repair capacity protects psoriasis patients against chemically induced basal cell carcinoma [Dybdahl et al. Mutat. Res. 433 (1999) 15-22]. We have used the same study persons to investigate the correlation between expression of eight genes involved in nucleotide excision repair and DNA repair capacity. mRNA levels of XPA, XPB, XPC, XPD, XPF, XPG, CSB and ERCC1 in primary lymphocytes from 33 individuals were quantified by dot-blots and normalized to -actin. ERCC1 and XPD mRNA quantities were highly correlated (r=0.89; P

U2 - 10.1016/S0921-8777(00)00051-3

DO - 10.1016/S0921-8777(00)00051-3

M3 - Journal article

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SP - 197

EP - 210

JO - Mutat Res

JF - Mutat Res

IS - 3

ER -

DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes.

Abstract

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