TY - JOUR
T1 - Dose-response association of handgrip strength and risk of depression: A longitudinal study of 115 601 older adults from 24 countries
AU - López-Bueno, Rubén
AU - Calatayud, Joaquín
AU - Andersen, Lars Louis
AU - Casaña, José
AU - Koyanagi, Ai
AU - Del Pozo Cruz, Borja
AU - Smith, Lee
PY - 2023/3
Y1 - 2023/3
N2 - BACKGROUND: Prior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations.AIMS: This study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over.METHOD: Data on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines.RESULTS: A total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9-11.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women.CONCLUSIONS: Being physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.
AB - BACKGROUND: Prior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations.AIMS: This study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over.METHOD: Data on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines.RESULTS: A total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9-11.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women.CONCLUSIONS: Being physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.
KW - Journal Article
KW - Depression/epidemiology
KW - Humans
KW - Middle Aged
KW - Aging
KW - Female
KW - Male
KW - Aged
KW - Longitudinal Studies
KW - Retirement
KW - Hand Strength/physiology
U2 - 10.1192/bjp.2022.178
DO - 10.1192/bjp.2022.178
M3 - Journal article
C2 - 36464972
SN - 0007-1250
VL - 222
SP - 135
EP - 142
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 3
ER -