Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study

Daniele Campa; Alessandro Martino; Angelica Macauda; Marek Dudziński; Anna Suska; Agnieszka Druzd-Sitek; Marc-Steffen Raab; Victor Moreno; Stefanie Huhn; Aleksandra Butrym; Juan Sainz; Gergely Szombath; Marcin Rymko; Herlander Marques; Fabienne Lesueur; Annette Juul Vangsted; Ulla Vogel; Marcin Kruszewski; Edyta Subocz; Gabriele Buda; Elżbieta Iskierka-Jażdżewska; Rafael Ríos; Maximilian Merz; Ben Schöttker; Grzegorz Mazur; Emeline Perrial; Joaquin Martinez-Lopez; Katja Butterbach; Ramón García Sanz; Hartmut Goldschmidt; Hermann Brenner; Krzysztof Jamroziak; Rui Manuel Reis; Katalin Kadar; Charles Dumontet; Marzena Wątek; Eva Kannik Haastrup; Grzegorz Helbig; Artur Jurczyszyn; Andrés Jerez; Judit Varkonyi; Torben Barington; Norbert Grzasko; Jan Maciej Zaucha; Vibeke Andersen; Daria Zawirska; Federico Canzian

doi:10.1080/10428194.2018.1551536

Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study

Daniele Campa
, Alessandro Martino
, Angelica Macauda
, Marek Dudziński
, Anna Suska
, Agnieszka Druzd-Sitek
, Marc-Steffen Raab
, Victor Moreno
, Stefanie Huhn
, Aleksandra Butrym
, Juan Sainz
, Gergely Szombath
, Marcin Rymko
, Herlander Marques
, Fabienne Lesueur
, Annette Juul Vangsted
, Ulla Vogel
, Marcin Kruszewski
, Edyta Subocz
, Gabriele Buda

Elżbieta Iskierka-Jażdżewska, Rafael Ríos, Maximilian Merz, Ben Schöttker, Grzegorz Mazur, Emeline Perrial, Joaquin Martinez-Lopez, Katja Butterbach, Ramón García Sanz, Hartmut Goldschmidt, Hermann Brenner, Krzysztof Jamroziak, Rui Manuel Reis, Katalin Kadar, Charles Dumontet, Marzena Wątek, Eva Kannik Haastrup, Grzegorz Helbig, Artur Jurczyszyn, Andrés Jerez, Judit Varkonyi, Torben Barington, Norbert Grzasko, Jan Maciej Zaucha, Vibeke Andersen, Daria Zawirska, Federico Canzian

Department of Biology, University of Pisa, Pisa, Italy.
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hematology Department, Teaching Hospital No 1, Rzeszów, Poland.
Department of Hematology, Jagiellonian University Medical College, Cracow, Poland.
Lymphoma Department, Centre of Oncology-Institute of Maria Skłodowska-Curie, Warsaw, Poland.
Max-Eder Research Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), IDIBELL, CIBERESP and Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Molecular Biology Laboratory, Section of Multiple Myeloma, Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland.
Pharmacogenetics Unit. Instituto de Investigación Biosanitaria de Granada (Ibs. Granada), Hospitales Universitarios de Granada / Universidad de Granada , Granada , Spain.
Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Department of Haematology, Copernicus Town Hospital of Torun, Torun, Poland.
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
PSL University, Paris, France.
Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Denmark.
Department of Hematology, University Hospital, Bydgoszcz, Poland.
Department of Haematology, Military Institute of Medicine, Warsaw, Poland.
Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Hematology, Copernicus Memorial Hospital, Medical University of Lodz, Lodz, Poland.
f Department of Internal Medicine V , Heidelberg University Hospital , Heidelberg , Germany.
Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.
Hospital 12 de Octubre, Complutense University, CNIO, CIBERONC, Madrid, Spain.
Department of Hematology, University Hospital of Salamanca, Salamanca, Spain.
National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Barretos Cancer Hospital, Molecular Oncology Research Center, S. Paulo, Brazil.
Department of Hematology, Holy Cross Oncology Center, Kielce, Poland.
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland.
Department of Hematology, University Hospital Morales Meseguer, IMIB, Murcia, Spain.
Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland.
Department of Hematology, Sea Hospital, Gdynia, Poland.
Institute of Molecular Biology, University of Southern Denmark, Odense, Denmark.
Department of Haematology, University Hospital of Cracow, Cracow, Poland.
Cancer Research Center of Lyon, INSERM, University of Lyon, Lyon, France.

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.

Original language	English
Journal	Leukemia and Lymphoma
Volume	60
Issue number	7
Pages (from-to)	1803-1811
ISSN	1042-8194
DOIs	https://doi.org/10.1080/10428194.2018.1551536
Publication status	Published - 11 Jan 2019

Keywords

Journal Article

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10.1080/10428194.2018.1551536

Cite this

Campa, D., Martino, A., Macauda, A., Dudziński, M., Suska, A., Druzd-Sitek, A., Raab, M.-S., Moreno, V., Huhn, S., Butrym, A., Sainz, J., Szombath, G., Rymko, M., Marques, H., Lesueur, F., Vangsted, A. J., Vogel, U., Kruszewski, M., Subocz, E., ... Canzian, F. (2019). Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study. Leukemia and Lymphoma, 60(7), 1803-1811. https://doi.org/10.1080/10428194.2018.1551536

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title = "Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study",

abstract = "Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.",

keywords = "Journal Article",

author = "Daniele Campa and Alessandro Martino and Angelica Macauda and Marek Dudzi{\'n}ski and Anna Suska and Agnieszka Druzd-Sitek and Marc-Steffen Raab and Victor Moreno and Stefanie Huhn and Aleksandra Butrym and Juan Sainz and Gergely Szombath and Marcin Rymko and Herlander Marques and Fabienne Lesueur and Vangsted, \{Annette Juul\} and Ulla Vogel and Marcin Kruszewski and Edyta Subocz and Gabriele Buda and El{\.z}bieta Iskierka-Ja{\.z}d{\.z}ewska and Rafael R{\'i}os and Maximilian Merz and Ben Sch{\"o}ttker and Grzegorz Mazur and Emeline Perrial and Joaquin Martinez-Lopez and Katja Butterbach and \{Garc{\'i}a Sanz\}, Ram{\'o}n and Hartmut Goldschmidt and Hermann Brenner and Krzysztof Jamroziak and Reis, \{Rui Manuel\} and Katalin Kadar and Charles Dumontet and Marzena W{\c a}tek and Haastrup, \{Eva Kannik\} and Grzegorz Helbig and Artur Jurczyszyn and Andr{\'e}s Jerez and Judit Varkonyi and Torben Barington and Norbert Grzasko and Zaucha, \{Jan Maciej\} and Vibeke Andersen and Daria Zawirska and Federico Canzian",

year = "2019",

month = jan,

day = "11",

doi = "10.1080/10428194.2018.1551536",

language = "English",

volume = "60",

pages = "1803--1811",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Taylor and Francis Ltd.",

number = "7",

}

Campa, D, Martino, A, Macauda, A, Dudziński, M, Suska, A, Druzd-Sitek, A, Raab, M-S, Moreno, V, Huhn, S, Butrym, A, Sainz, J, Szombath, G, Rymko, M, Marques, H, Lesueur, F, Vangsted, AJ, Vogel, U, Kruszewski, M, Subocz, E, Buda, G, Iskierka-Jażdżewska, E, Ríos, R, Merz, M, Schöttker, B, Mazur, G, Perrial, E, Martinez-Lopez, J, Butterbach, K, García Sanz, R, Goldschmidt, H, Brenner, H, Jamroziak, K, Reis, RM, Kadar, K, Dumontet, C, Wątek, M, Haastrup, EK, Helbig, G, Jurczyszyn, A, Jerez, A, Varkonyi, J, Barington, T, Grzasko, N, Zaucha, JM, Andersen, V, Zawirska, D & Canzian, F 2019, 'Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study', Leukemia and Lymphoma, vol. 60, no. 7, pp. 1803-1811. https://doi.org/10.1080/10428194.2018.1551536

TY - JOUR

T1 - Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study

AU - Campa, Daniele

AU - Martino, Alessandro

AU - Macauda, Angelica

AU - Dudziński, Marek

AU - Suska, Anna

AU - Druzd-Sitek, Agnieszka

AU - Raab, Marc-Steffen

AU - Moreno, Victor

AU - Huhn, Stefanie

AU - Butrym, Aleksandra

AU - Sainz, Juan

AU - Szombath, Gergely

AU - Rymko, Marcin

AU - Marques, Herlander

AU - Lesueur, Fabienne

AU - Vangsted, Annette Juul

AU - Vogel, Ulla

AU - Kruszewski, Marcin

AU - Subocz, Edyta

AU - Buda, Gabriele

AU - Iskierka-Jażdżewska, Elżbieta

AU - Ríos, Rafael

AU - Merz, Maximilian

AU - Schöttker, Ben

AU - Mazur, Grzegorz

AU - Perrial, Emeline

AU - Martinez-Lopez, Joaquin

AU - Butterbach, Katja

AU - García Sanz, Ramón

AU - Goldschmidt, Hartmut

AU - Brenner, Hermann

AU - Jamroziak, Krzysztof

AU - Reis, Rui Manuel

AU - Kadar, Katalin

AU - Dumontet, Charles

AU - Wątek, Marzena

AU - Haastrup, Eva Kannik

AU - Helbig, Grzegorz

AU - Jurczyszyn, Artur

AU - Jerez, Andrés

AU - Varkonyi, Judit

AU - Barington, Torben

AU - Grzasko, Norbert

AU - Zaucha, Jan Maciej

AU - Andersen, Vibeke

AU - Zawirska, Daria

AU - Canzian, Federico

PY - 2019/1/11

Y1 - 2019/1/11

N2 - Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.

AB - Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.

KW - Journal Article

U2 - 10.1080/10428194.2018.1551536

DO - 10.1080/10428194.2018.1551536

M3 - Journal article

C2 - 30633655

SN - 1042-8194

VL - 60

SP - 1803

EP - 1811

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 7

ER -

Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: An IMMEnSE study

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