Genetic variations in pattern recognition receptor loci are associated with anti-TNF response in patients with rheumatoid arthritis

J. Sode; Ulla Birgitte Vogel; S. Bank; P.S. Andersen; M.L. Hetland; H. Locht; N.H. Heegaard; V. Andersen

doi:10.1371/journal.pone.0139781

Genetic variations in pattern recognition receptor loci are associated with anti-TNF response in patients with rheumatoid arthritis

J. Sode
, Ulla Birgitte Vogel
, S. Bank
, P.S. Andersen
, M.L. Hetland
, H. Locht
, N.H. Heegaard
, V. Andersen

Department of Chemistry and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

[Open access] OBJECTIVES: To determine whether genetic variation within genes related to the Toll-like receptor, inflammasome and interferon-gamma pathways contributes to the differences in treatment response to tumour necrosis factor inhibitors (anti-TNF) in patients with rheumatoid arthritis (RA). METHODS: In a retrospective case-case study, we assessed 23 functional single nucleotide polymorphisms (SNPs) in 15 genes. We included 538 anti-TNF naive Danish RA patients from the nationwide DANBIO database. Multivariable logistic regression analyses were performed to detect associations (p-value

Original language	Danish
Journal	PLoS One
Volume	10
Issue number	10
Pages (from-to)	e0139781-
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0139781
Publication status	Published - 2015

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10.1371/journal.pone.0139781

Cite this

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abstract = "[Open access] OBJECTIVES: To determine whether genetic variation within genes related to the Toll-like receptor, inflammasome and interferon-gamma pathways contributes to the differences in treatment response to tumour necrosis factor inhibitors (anti-TNF) in patients with rheumatoid arthritis (RA). METHODS: In a retrospective case-case study, we assessed 23 functional single nucleotide polymorphisms (SNPs) in 15 genes. We included 538 anti-TNF naive Danish RA patients from the nationwide DANBIO database. Multivariable logistic regression analyses were performed to detect associations (p-value",

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AU - Sode, J.

AU - Vogel, Ulla Birgitte

AU - Bank, S.

AU - Andersen, P.S.

AU - Hetland, M.L.

AU - Locht, H.

AU - Heegaard, N.H.

AU - Andersen, V.

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AB - [Open access] OBJECTIVES: To determine whether genetic variation within genes related to the Toll-like receptor, inflammasome and interferon-gamma pathways contributes to the differences in treatment response to tumour necrosis factor inhibitors (anti-TNF) in patients with rheumatoid arthritis (RA). METHODS: In a retrospective case-case study, we assessed 23 functional single nucleotide polymorphisms (SNPs) in 15 genes. We included 538 anti-TNF naive Danish RA patients from the nationwide DANBIO database. Multivariable logistic regression analyses were performed to detect associations (p-value

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