Abstract
Objective: Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.Methods: Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.Results: No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).Conclusion: The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.
| Original language | Danish |
|---|---|
| Journal | European Journal of Gastroenterology & Hepatology |
| Volume | 23 |
| Issue number | 3 |
| Pages (from-to) | 282-285 |
| Number of pages | 4 |
| ISSN | 0954-691X |
| DOIs | |
| Publication status | Published - 2011 |
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