Intestinal PTGS2 mRNA Levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis

L.K. Vogel; M. Saebo; H. Hoyer; T.I. Kopp; Ulla Birgitte Vogel; S. Godiksen; F.B. Frenzel; J. Hamfjord; I.M. Bowitz-Lothe; E. Johnson; E.H. Kure; V. Andersen

doi:10.1371/journal.pone.0105254

Intestinal PTGS2 mRNA Levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis

L.K. Vogel
, M. Saebo
, H. Hoyer
, T.I. Kopp
, Ulla Birgitte Vogel
, S. Godiksen
, F.B. Frenzel
, J. Hamfjord
, I.M. Bowitz-Lothe
, E. Johnson
, E.H. Kure
, V. Andersen

Department of Chemistry and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

[Open access]BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

Original language	English
Journal	PLoS One
Volume	9
Issue number	8
Pages (from-to)	e105254-
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0105254
Publication status	Published - 2014

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title = "Intestinal PTGS2 mRNA Levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis",

abstract = "[Open access]BACKGROUND \& AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P",

author = "L.K. Vogel and M. Saebo and H. Hoyer and T.I. Kopp and Vogel, \{Ulla Birgitte\} and S. Godiksen and F.B. Frenzel and J. Hamfjord and I.M. Bowitz-Lothe and E. Johnson and E.H. Kure and V. Andersen",

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doi = "10.1371/journal.pone.0105254",

language = "English",

volume = "9",

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TY - JOUR

T1 - Intestinal PTGS2 mRNA Levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis

AU - Vogel, L.K.

AU - Saebo, M.

AU - Hoyer, H.

AU - Kopp, T.I.

AU - Vogel, Ulla Birgitte

AU - Godiksen, S.

AU - Frenzel, F.B.

AU - Hamfjord, J.

AU - Bowitz-Lothe, I.M.

AU - Johnson, E.

AU - Kure, E.H.

AU - Andersen, V.

N1 - SUBMISSIONYEAR:2014

PY - 2014

Y1 - 2014

N2 - [Open access]BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

AB - [Open access]BACKGROUND & AIMS: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. METHODS: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. RESULTS: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P

U2 - 10.1371/journal.pone.0105254

DO - 10.1371/journal.pone.0105254

M3 - Journal article

SN - 1932-6203

VL - 9

SP - e105254-

JO - PLoS One

JF - PLoS One

IS - 8

ER -

Intestinal PTGS2 mRNA Levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis

Abstract

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