Maternal life and work stressors during pregnancy and asthma in offspring

Kathrine Pape; Xiaoqin Liu; Camilla Sandal Sejbæk; Niklas Worm Andersson; Ann Dyreborg Larsen; Hans Bay; Henrik Albert Kolstad; Jens Peter Ellekilde Bonde; Jørn Olsen; Cecilie Svanes; Kirsten Skamstrup Hansen; Reiner Rugulies; Karin Sørig Hougaard; Vivi Schlünssen

doi:10.1093/ije/dyaa133

Maternal life and work stressors during pregnancy and asthma in offspring

Kathrine Pape
, Xiaoqin Liu
, Camilla Sandal Sejbæk
, Niklas Worm Andersson
, Ann Dyreborg Larsen
, Hans Bay
, Henrik Albert Kolstad
, Jens Peter Ellekilde Bonde
, Jørn Olsen
, Cecilie Svanes
, Kirsten Skamstrup Hansen
, Reiner Rugulies
, Karin Sørig Hougaard
, Vivi Schlünssen

NCRR-National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus University, Denmark.
Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospitals, Copenhagen, Denmark.
Department of Clinical Medicine, Occupational Medicine, Aarhus University, Aarhus, Denmark.
Institute of Public Health, Copenhagen University, Copenhagen, Denmark.
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
Department of Paediatrics, Herlev and Gentofte Hospital, Hellerup, Denmark.
Department of Public Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.
Department of linical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.
Department of Occupational and Environmental Medicine, Frederiksberg and Bispebjerg Hospital, Copenhagen, Denmark.
Dept of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Department of Psychology, University of Copenhagen, Copenhagen, Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

BACKGROUND: Maternal stressors during pregnancy are potential risk factors for asthma in offspring. However, previous studies have been limited by the use of self-reported data focusing on stressors either in private life or at work. This study examined the association between maternal stressors both in private life and at work during pregnancy and asthma in offspring.

METHODS: In the Danish National Birth Cohort, 75 156 live-born singletons born during 1996-2002 were identified. Maternal information on job title were available around weeks 12-16 of gestation. Data on maternal bereavement, life-threatening illness, suicide attempt and alcohol or drug abuse of a close relative and offspring childhood asthma (3-10 years of age) were obtained from Danish nationwide registers. Maternal psychosocial work stressors (job control, psychological job demands, emotional job demands, work-related violence and threats of work-related violence) were estimated by the use of job-exposure matrices. The association between maternal stress and childhood asthma was analysed in Cox models adjusted for maternal age, comorbidity and parity.

RESULTS: Neither private-life nor work stressors were related to onset of asthma in offspring. Separate analyses by parental atopy or onset of asthma in offspring supported the main findings.

CONCLUSIONS: This study does not support an elevated risk of childhood asthma related to exposure to stress during pregnancy.

Original language	English
Journal	International Journal of Epidemiology
Volume	49
Issue number	6
Pages (from-to)	1847-1855
ISSN	0300-5771
DOIs	https://doi.org/10.1093/ije/dyaa133
Publication status	Published - Jan 2021

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10.1093/ije/dyaa133

EN -Prænatal stress og allergi
Schlünssen, V. (Project Manager), Bay, H. (Project Participant), Madsen, K. P. (Project Participant), Hougaard, K. S. (Project Participant), Sejbæk, C. S. (Project Participant) & Pedersen, L. R. M. (Project Participant)
01/01/2016 → 31/12/2019
Project: Research

Ph.d.-vejledning: Maternal stress at work and in private life during pregnancy: Implications for development of asthma and other allergic diseases in their children
Hougaard, K. S. (Supervisor - Ph.d.) & Schlünssen, V. (Supervisor - Ph.d.)
2017 → 2020
Activity: Other

Cite this

Pape, K., Liu, X., Sejbæk, C. S., Andersson, N. W., Larsen, A. D., Bay, H., Kolstad, H. A., Bonde, J. P. E., Olsen, J., Svanes, C., Hansen, K. S., Rugulies, R., Hougaard, K. S., & Schlünssen, V. (2021). Maternal life and work stressors during pregnancy and asthma in offspring. International Journal of Epidemiology, 49(6), 1847-1855. https://doi.org/10.1093/ije/dyaa133

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abstract = "BACKGROUND: Maternal stressors during pregnancy are potential risk factors for asthma in offspring. However, previous studies have been limited by the use of self-reported data focusing on stressors either in private life or at work. This study examined the association between maternal stressors both in private life and at work during pregnancy and asthma in offspring.METHODS: In the Danish National Birth Cohort, 75 156 live-born singletons born during 1996-2002 were identified. Maternal information on job title were available around weeks 12-16 of gestation. Data on maternal bereavement, life-threatening illness, suicide attempt and alcohol or drug abuse of a close relative and offspring childhood asthma (3-10 years of age) were obtained from Danish nationwide registers. Maternal psychosocial work stressors (job control, psychological job demands, emotional job demands, work-related violence and threats of work-related violence) were estimated by the use of job-exposure matrices. The association between maternal stress and childhood asthma was analysed in Cox models adjusted for maternal age, comorbidity and parity.RESULTS: Neither private-life nor work stressors were related to onset of asthma in offspring. Separate analyses by parental atopy or onset of asthma in offspring supported the main findings.CONCLUSIONS: This study does not support an elevated risk of childhood asthma related to exposure to stress during pregnancy.",

keywords = "Luftvejslidelser",

author = "Kathrine Pape and Xiaoqin Liu and Sejb{\ae}k, \{Camilla Sandal\} and Andersson, \{Niklas Worm\} and Larsen, \{Ann Dyreborg\} and Hans Bay and Kolstad, \{Henrik Albert\} and Bonde, \{Jens Peter Ellekilde\} and J{\o}rn Olsen and Cecilie Svanes and Hansen, \{Kirsten Skamstrup\} and Reiner Rugulies and Hougaard, \{Karin S{\o}rig\} and Vivi Schl{\"u}nssen",

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year = "2021",

month = jan,

doi = "10.1093/ije/dyaa133",

language = "English",

volume = "49",

pages = "1847--1855",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

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T1 - Maternal life and work stressors during pregnancy and asthma in offspring

AU - Pape, Kathrine

AU - Liu, Xiaoqin

AU - Sejbæk, Camilla Sandal

AU - Andersson, Niklas Worm

AU - Larsen, Ann Dyreborg

AU - Bay, Hans

AU - Kolstad, Henrik Albert

AU - Bonde, Jens Peter Ellekilde

AU - Olsen, Jørn

AU - Svanes, Cecilie

AU - Hansen, Kirsten Skamstrup

AU - Rugulies, Reiner

AU - Hougaard, Karin Sørig

AU - Schlünssen, Vivi

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2021/1

Y1 - 2021/1

N2 - BACKGROUND: Maternal stressors during pregnancy are potential risk factors for asthma in offspring. However, previous studies have been limited by the use of self-reported data focusing on stressors either in private life or at work. This study examined the association between maternal stressors both in private life and at work during pregnancy and asthma in offspring.METHODS: In the Danish National Birth Cohort, 75 156 live-born singletons born during 1996-2002 were identified. Maternal information on job title were available around weeks 12-16 of gestation. Data on maternal bereavement, life-threatening illness, suicide attempt and alcohol or drug abuse of a close relative and offspring childhood asthma (3-10 years of age) were obtained from Danish nationwide registers. Maternal psychosocial work stressors (job control, psychological job demands, emotional job demands, work-related violence and threats of work-related violence) were estimated by the use of job-exposure matrices. The association between maternal stress and childhood asthma was analysed in Cox models adjusted for maternal age, comorbidity and parity.RESULTS: Neither private-life nor work stressors were related to onset of asthma in offspring. Separate analyses by parental atopy or onset of asthma in offspring supported the main findings.CONCLUSIONS: This study does not support an elevated risk of childhood asthma related to exposure to stress during pregnancy.

AB - BACKGROUND: Maternal stressors during pregnancy are potential risk factors for asthma in offspring. However, previous studies have been limited by the use of self-reported data focusing on stressors either in private life or at work. This study examined the association between maternal stressors both in private life and at work during pregnancy and asthma in offspring.METHODS: In the Danish National Birth Cohort, 75 156 live-born singletons born during 1996-2002 were identified. Maternal information on job title were available around weeks 12-16 of gestation. Data on maternal bereavement, life-threatening illness, suicide attempt and alcohol or drug abuse of a close relative and offspring childhood asthma (3-10 years of age) were obtained from Danish nationwide registers. Maternal psychosocial work stressors (job control, psychological job demands, emotional job demands, work-related violence and threats of work-related violence) were estimated by the use of job-exposure matrices. The association between maternal stress and childhood asthma was analysed in Cox models adjusted for maternal age, comorbidity and parity.RESULTS: Neither private-life nor work stressors were related to onset of asthma in offspring. Separate analyses by parental atopy or onset of asthma in offspring supported the main findings.CONCLUSIONS: This study does not support an elevated risk of childhood asthma related to exposure to stress during pregnancy.

KW - Luftvejslidelser

U2 - 10.1093/ije/dyaa133

DO - 10.1093/ije/dyaa133

M3 - Journal article

C2 - 32974645

SN - 0300-5771

VL - 49

SP - 1847

EP - 1855

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 6

ER -

Maternal life and work stressors during pregnancy and asthma in offspring

Abstract

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Projects

EN -Prænatal stress og allergi

Activities

Ph.d.-vejledning: Maternal stress at work and in private life during pregnancy: Implications for development of asthma and other allergic diseases in their children

Cite this