PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

R.K. Petersen; S.B. Larsen; D.M. Jensen; Jane Christensen; A. Olsen; S. Loft; C. Nellemann; K. Overvad; K. Kristiansen; A. Tjønneland; Ulla Birgitte Vogel

doi:10.1016/j.canlet.2011.10.009

PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

R.K. Petersen
, S.B. Larsen
, D.M. Jensen
, Jane Christensen
, A. Olsen
, S. Loft
, C. Nellemann
, K. Overvad
, K. Kristiansen
, A. Tjønneland
, Ulla Birgitte Vogel

Department of Chemistry and Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR? inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR? and the PPAR?-PGC-1a complex was inhibited by ethanol. PPAR? 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR? 12Pro-PGC-1a complex. Our results suggest that PPAR? and PGC-1a activity is an important determinant of alcohol related breast cancer.

Original language	English
Journal	Cancer Letters
Volume	315
Issue number	1
Pages (from-to)	59-68
Number of pages	10
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2011.10.009
Publication status	Published - 2012

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10.1016/j.canlet.2011.10.009

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title = "PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer",

abstract = "Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR? inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR? and the PPAR?-PGC-1a complex was inhibited by ethanol. PPAR? 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR? 12Pro-PGC-1a complex. Our results suggest that PPAR? and PGC-1a activity is an important determinant of alcohol related breast cancer.",

author = "R.K. Petersen and S.B. Larsen and D.M. Jensen and Jane Christensen and A. Olsen and S. Loft and C. Nellemann and K. Overvad and K. Kristiansen and A. Tj{\o}nneland and Vogel, \{Ulla Birgitte\}",

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doi = "10.1016/j.canlet.2011.10.009",

language = "English",

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TY - JOUR

T1 - PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

AU - Petersen, R.K.

AU - Larsen, S.B.

AU - Jensen, D.M.

AU - Christensen, Jane

AU - Olsen, A.

AU - Loft, S.

AU - Nellemann, C.

AU - Overvad, K.

AU - Kristiansen, K.

AU - Tjønneland, A.

AU - Vogel, Ulla Birgitte

N1 - SUBMISSIONYEAR:2012

PY - 2012

Y1 - 2012

N2 - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR? inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR? and the PPAR?-PGC-1a complex was inhibited by ethanol. PPAR? 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR? 12Pro-PGC-1a complex. Our results suggest that PPAR? and PGC-1a activity is an important determinant of alcohol related breast cancer.

AB - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR? inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR? and the PPAR?-PGC-1a complex was inhibited by ethanol. PPAR? 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR? 12Pro-PGC-1a complex. Our results suggest that PPAR? and PGC-1a activity is an important determinant of alcohol related breast cancer.

U2 - 10.1016/j.canlet.2011.10.009

DO - 10.1016/j.canlet.2011.10.009

M3 - Journal article

SN - 0304-3835

VL - 315

SP - 59

EP - 68

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

Abstract

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