Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Niels Hadrup; Anne T. Saber; Zdenka O. Kyjovska; Nicklas R. Jacobsen; Minnamari Vippola; Essi Sarlin; Yaobo Ding; Otmar Schmid; Håkan Wallin; Keld A. Jensen; Ulla Vogel

doi:10.1016/j.etap.2019.103303

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Niels Hadrup
, Anne T. Saber
, Zdenka O. Kyjovska
, Nicklas R. Jacobsen
, Minnamari Vippola
, Essi Sarlin
, Yaobo Ding
, Otmar Schmid
, Håkan Wallin
, Keld A. Jensen
, Ulla Vogel

Tampere University
Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich, Germany.
German Research Center for Environmental Health (GmbH), Munich, Germany.
National Institute of Occupational Health (STAMI), Oslo, Norway.
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

Original language	Danish
Journal	Environmental Toxicology and Pharmacology
Volume	74
Pages (from-to)	103303
ISSN	1382-6689
DOIs	https://doi.org/10.1016/j.etap.2019.103303
Publication status	Published - 2020

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10.1016/j.etap.2019.103303

Danish NanoSafety Centre
Vogel, U. B. (Project Manager), Hougaard, K. S. (Project Participant), Frederiksen, M. (Project Participant), Clausen, P. A. (Project Participant), Saber, A. T. (Project Participant), Berthing, T. (Project Participant), Jacobsen, N. R. (Project Participant), Jensen, K. A. (Project Participant), Mortensen, A. (Project Participant), Poulsen, S. S. (Project Participant), Koivisto, A. J. (Project Participant), Jensen, A. C. Ø. (Project Participant), Brostrøm, A. (Project Participant), Skovmand, A. (Project Participant), Andersen, M. H. G. (Project Participant) & Koivisto, J. M. (Project Participant)
01/05/2016 → 31/08/2019
Project: Research
EN -Nanodevice, WP20
Jensen, K. A. (Project Manager)
01/01/2009 → 31/05/2013
Project: Research

Cite this

@article{57d3655fceb74a17af67b1b0c59370a1,

title = "Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks",

abstract = "Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation {\textendash} neutrophil influx into bronchoalveolar lavage (BAL) fluid {\textendash} occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.",

keywords = "Nanomaterial, Iron, Nickel, Zinc, Pulmonary, Metal oxides",

author = "Niels Hadrup and Saber, \{Anne T.\} and Kyjovska, \{Zdenka O.\} and Jacobsen, \{Nicklas R.\} and Minnamari Vippola and Essi Sarlin and Yaobo Ding and Otmar Schmid and H{\aa}kan Wallin and Jensen, \{Keld A.\} and Ulla Vogel",

note = "2020",

year = "2020",

doi = "10.1016/j.etap.2019.103303",

language = "Dansk",

volume = "74",

pages = " 103303",

journal = "Environmental Toxicology and Pharmacology",

issn = "1382-6689",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

AU - Hadrup, Niels

AU - Saber, Anne T.

AU - Kyjovska, Zdenka O.

AU - Jacobsen, Nicklas R.

AU - Vippola, Minnamari

AU - Sarlin, Essi

AU - Ding, Yaobo

AU - Schmid, Otmar

AU - Wallin, Håkan

AU - Jensen, Keld A.

AU - Vogel, Ulla

N1 - 2020

PY - 2020

Y1 - 2020

N2 - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

AB - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

KW - Nanomaterial

KW - Iron

KW - Nickel

KW - Zinc

KW - Pulmonary

KW - Metal oxides

U2 - 10.1016/j.etap.2019.103303

DO - 10.1016/j.etap.2019.103303

M3 - Tidsskriftartikel

SN - 1382-6689

VL - 74

SP - 103303

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

ER -

Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Abstract

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Projects

Danish NanoSafety Centre

EN -Nanodevice, WP20

Cite this