The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies

Shareen H. Doak; Martin J. D. Clift; Anna Costa; Christiaan Delmaar; Ilse Gosens; Sabina Halappanavar; Sean Kelly; Willie J. G. M. Pejinenburg; Barbara Rothen-Rutishauser; Roel P. F. Schins; Vicki Stone; Lang Tran; Martina G. Vijver; Ulla Vogel; Wendel Wohlleben; Flemming R. Cassee

doi:10.1002/smll.202200231

The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies

Shareen H. Doak
, Martin J. D. Clift
, Anna Costa
, Christiaan Delmaar
, Ilse Gosens
, Sabina Halappanavar
, Sean Kelly
, Willie J. G. M. Pejinenburg
, Barbara Rothen-Rutishauser
, Roel P. F. Schins
, Vicki Stone
, Lang Tran
, Martina G. Vijver
, Ulla Vogel
, Wendel Wohlleben
, Flemming R. Cassee

Department of Chemistry and Microbiology

Swansea University
CNR-ISTEC, Faenza, RA, Italy.
National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
NANOTECHNOLOGY INDUSTRIES ASSOCIATION (NIA)
Leiden University
University of Fribourg
Leibniz Research Institute for Environmental Medicine
Heriot-Watt University
Institute of Occupational Medicine, Edinburgh, Scotland, UK.

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Abstract The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

Original language	Danish
Journal	Small
Pages (from-to)	2200231
ISSN	1613-6810
DOIs	https://doi.org/10.1002/smll.202200231
Publication status	Published - 24 Mar 2022

Keywords

nanomaterials
nanosafety

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10.1002/smll.202200231

1 Finished
1 Active

FFIKA: Fornyet fokus på forskning i kemisk arbejdsmiljø
Vogel, U. B. (Project Manager), Jensen, K. A. (Project Participant), Jensen, A. C. Ø. (Project Participant), Berthing, T. (Project Participant), Andersen, M. H. G. (Project Participant), Hougaard, K. S. (Project Participant), Clausen, P. A. (Project Participant), Frederiksen, M. (Project Participant), Mortensen, A. (Project Participant), Saber, A. T. (Project Participant), Jacobsen, N. R. (Project Participant), Akhtar, Y. (Project Participant), Asp, A.-K. (Project Participant), Abildtrup, A. (Project Participant), Tegner, U. (Project Participant), Terrida, E. B. (Project Participant), Guldbrandsen, M. (Project Participant), Kembouche, Y. (Project Participant), Kofoed-Sørensen, V. (Project Participant), Nielsen, S. H. (Project Participant), Sahlgren, N. M. (Project Participant), Fonseca, A. S. (Project Participant), Danielsen, P. H. (Project Participant), Sørli, J. B. (Project Participant), Hadrup, N. (Project Participant), Ardenkjær-Skinnerup, J. (Project Participant), Nøjgaard, J. N. K. (Project Participant), Jørgensen, A. K. (Project Participant), Gutierrez, C. A. T. (Project Participant) & Brostrøm, A. (Project Participant)
01/01/2020 → 31/12/2026
Project: Research
PATROLS: Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment
Berthing, T. (Project Manager), Jensen, K. A. (Project Manager), Vogel, U. B. (Project Manager), Mortensen, A. (Project Participant), Clausen, P. A. (Project Participant) & Jacobsen, N. R. (Project Participant)
01/01/2018 → 30/06/2021
Project: Research

Cite this

Doak, S. H., Clift, M. J. D., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W. J. G. M., Rothen-Rutishauser, B., Schins, R. P. F., Stone, V., Tran, L., Vijver, M. G., Vogel, U., Wohlleben, W., & Cassee, F. R. (2022). The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies. Small, 2200231. https://doi.org/10.1002/smll.202200231

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title = "The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies",

abstract = "Abstract The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.",

keywords = "nanomaterials, nanosafety",

author = "Doak, \{Shareen H.\} and Clift, \{Martin J. D.\} and Anna Costa and Christiaan Delmaar and Ilse Gosens and Sabina Halappanavar and Sean Kelly and Pejinenburg, \{Willie J. G. M.\} and Barbara Rothen-Rutishauser and Schins, \{Roel P. F.\} and Vicki Stone and Lang Tran and Vijver, \{Martina G.\} and Ulla Vogel and Wendel Wohlleben and Cassee, \{Flemming R.\}",

note = "https://doi.org/10.1002/smll.202200231",

year = "2022",

month = mar,

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doi = "10.1002/smll.202200231",

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Doak, SH, Clift, MJD, Costa, A, Delmaar, C, Gosens, I, Halappanavar, S, Kelly, S, Pejinenburg, WJGM, Rothen-Rutishauser, B, Schins, RPF, Stone, V, Tran, L, Vijver, MG, Vogel, U, Wohlleben, W & Cassee, FR 2022, 'The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies', Small, pp. 2200231. https://doi.org/10.1002/smll.202200231

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T1 - The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies

AU - Doak, Shareen H.

AU - Clift, Martin J. D.

AU - Costa, Anna

AU - Delmaar, Christiaan

AU - Gosens, Ilse

AU - Halappanavar, Sabina

AU - Kelly, Sean

AU - Pejinenburg, Willie J. G. M.

AU - Rothen-Rutishauser, Barbara

AU - Schins, Roel P. F.

AU - Stone, Vicki

AU - Tran, Lang

AU - Vijver, Martina G.

AU - Vogel, Ulla

AU - Wohlleben, Wendel

AU - Cassee, Flemming R.

N1 - https://doi.org/10.1002/smll.202200231

PY - 2022/3/24

Y1 - 2022/3/24

N2 - Abstract The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

AB - Abstract The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

KW - nanomaterials

KW - nanosafety

U2 - 10.1002/smll.202200231

DO - 10.1002/smll.202200231

M3 - Tidsskriftartikel

SN - 1613-6810

SP - 2200231

JO - Small

JF - Small

ER -

The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability—A PATROLS perspective on new approach methodologies

Abstract

Keywords

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Projects

FFIKA: Fornyet fokus på forskning i kemisk arbejdsmiljø

PATROLS: Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment

Cite this