Occupational physical activity and risk of mortality in women and men: the Tromsø Study 1986-2021

Edvard H Sagelv, Knut Eirik Dalene, Anne Elise Eggen, Ulf Ekelund, Marius Steiro Fimland, Kim Arne Heitmann, Andreas Holtermann, Kristoffer Robin Johansen, Maja-Lisa Løchen, Bente Morseth, Tom Wilsgaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Associations between occupational physical activity (OPA) and mortality risks are inconclusive. We aimed to examine associations between (1) OPA separately and (2) jointly with leisure time physical activity (LTPA), and risk of all-cause, cardiovascular disease (CVD) and cancer mortality, over four decades with updated exposure and covariates every 6-8 years.

METHODS: Adults aged 20-65 years from the Tromsø Study surveys Tromsø3-Tromsø7 (1986-2016) were included. We categorised OPA as low (sedentary), moderate (walking work), high (walking+lifting work) or very high (heavy manual labour) and LTPA as inactive, moderate and vigorous. We used Cox/Fine and Gray regressions to examine associations, adjusted for age, body mass index, smoking, education, diet, alcohol and LTPA (aim 1 only).

RESULTS: Of 29 605 participants with 44 140 total observations, 4131 (14.0%) died, 1057 (25.6%) from CVD and 1660 (40.4%) from cancer, during follow-up (median: 29.1 years, 25th-75th: 16.5.1-35.3). In men, compared with low OPA, high OPA was associated with lower all-cause (HR 0.83, 95% CI 0.74 to 0.92) and CVD (subdistributed HR (SHR) 0.68, 95% CI 0.54 to 0.84) but not cancer mortality (SHR 0.99, 95% CI 0.84 to 1.19), while no association was observed for moderate or very high OPA. In joint analyses using inactive LTPA and low OPA as reference, vigorous LTPA was associated with lower all-cause mortality combined with low (HR 0.75, 95% CI 0.64 to 0.89), high (HR 0.67, 95% CI 0.54 to 0.82) and very high OPA (HR 0.74, 95% CI 0.58 to 0.94), but not with moderate OPA. In women, there were no associations between OPA, or combined OPA and LTPA, with mortality.

CONCLUSION: High OPA, but not moderate and very high OPA, was associated with lower all-cause and CVD mortality risk in men but not in women. Vigorous LTPA was associated with lower mortality risk in men with low, high and very high OPA, but not moderate OPA.

Original languageEnglish
JournalBritish Journal of Sports Medicine
Volume58
Issue number2
Pages (from-to)81-88
Number of pages8
ISSN0306-3674
DOIs
Publication statusPublished - 3 Jan 2024

Keywords

  • Adult
  • Cardiovascular Diseases
  • Exercise
  • Female
  • Humans
  • Leisure Activities
  • Male
  • Neoplasms
  • Risk Factors

Fingerprint

Dive into the research topics of 'Occupational physical activity and risk of mortality in women and men: the Tromsø Study 1986-2021'. Together they form a unique fingerprint.

Cite this